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Nathan Pritikin (August 29, 1915 – February 21, 1985) was an American inventor, engineer, nutritionist and longevity researcher. He promoted the Pritikin diet, a high-carbohydrate low-fat plant-based diet combined with regular aerobic exercise to prevent cardiovascular disease. The Pritikin diet emphasizes the consumption of legumes, whole grains, fresh fruit and vegetables and non-fat dairy products with small amounts of lean meat, fowl and fish.

Dietitians and nutritionists have classified the Pritikin diet as a fad diet due to its restrictive nature and unsubstantiated health claims.

Some of Pritikin's dietary recommendations are in line with mainstream nutritional advice such as emphasizing vegetable consumption and restricting alcohol but his claims about his Program reversing atherosclerosis are not supported by clinical evidence. He was also criticized for making false statements such as "almost any amount of sugar is too much".

The American Medical Association have questioned the effectiveness of the diet for the diseases it is supposed to prevent and have warned that the lower calcium and iron intake may make it unsuitable for pregnant women. In 1985, Columbia University’s Institute of Human Nutrition suggested that the Pritikin Program may provide inadequate sources of calcium, copper and zinc.

Frederick J. Stare commented that the Pritikin diet is an "extremely restrictive plan" that is difficult to adhere to long-term and suggested that the diet may increase the risk of iron deficiency. He stated that the diet recommended by the American Medical Association is nutritionally balanced and more practical than the Pritikin diet. Alice H. Lichtenstein has suggested that the diet may be time consuming to plan and prepare meals and that there is a risk of fat-soluble vitamin deficiencies as the diet is extremely low in fat.

A 2023 review found that the Pritikin diet had no significant impact on all-cause mortality or cardiovascular outcomes.

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